NAD+ & Aging

NAD+ & Aging

Research shows NAD+ levels in the body decline by about 50% by the age of 50. By the age of 80, NAD+ levels are reduced to only 10%. This partially explains the decline in cognitive function and ability to repair cellular damage with aging.

NAD+ levels decline as we age, leading to a decline in the function of cells and organs. As you age, the telomeres in your DNA shorten which increases disease risk. Recent studies show that replenishment of NAD+ slows this process.

We administer iV NAD+ a highly effective method for delivering NAD+ over oral NAD+ supplements. We also offer nasal NAD+ spray.

Joint Pain Arthritis

Musculoskeletal pain affects the bones, muscles, ligaments, tendons, and nerves. It can be acute (having a rapid onset with severe symptoms) or chronic (long-lasting). Musculoskeletal pain can be localized in one area, or widespread.

Lower back pain is the most common type of musculoskeletal pain. Other common types include tendonitis, myalgia (muscle pain), and stress fractures.

It is most often caused by an injury to the bones, joints, muscles, tendons, ligaments, or nerves or can be the result of long-standing overuse syndromes or wear and tear type injuries. This can be caused by jerking movements, car accidents, falls, fractures, sprains, dislocations, and direct blows to the muscle.

Musculoskeletal pain can also be caused by overuse. Pain from overuse affects 33% of adults. Lower back pain from overuse is the most common work-related diagnosis in Western society.

Poor posture or prolonged immobilization can also cause musculoskeletal pain.

Symptoms of musculoskeletal pain depend on whether the pain is caused by an injury or overuse and whether it is chronic or acute. The symptoms can also differ from person to person.


  • Localized or widespread pain that can worsen with movement
  • Aching or stiffness of the entire body
  • The feeling that your muscles have been pulled or overworked
  • Fatigue
  • Sleep disturbances
  • Twitching muscles
  • The sensation of “burning” in your muscles


Fatigue can be described as the lack of energy and motivation (both physical and mental). This is different than drowsiness, a term that describes the need to sleep. Aside from drowsiness, other symptoms can be confused with Fatigue including shortness of breath with activity and muscle weakness. Again, all these symptoms can occur at the same time. Fatigue can be a normal response to physical and mental activity; in most normal individuals it is quickly relieved (usually in hours to about a day, depending on the intensity of the activity) by reducing the activity.

Fatigue is a very common complaint and it is important to remember that it is a symptom and not a disease. Many illnesses can result in the complaint of Fatigue and they can be physical, psychological, or a combination of the two.

Often, the symptom of Fatigue has a gradual onset and the person may not be aware of how much energy they have lost until they try to compare their ability to complete tasks from one time frame to another. They may presume that their Fatigue is due to aging and ignore the symptom. This may lead to a delay in seeking care.


Individuals who are having accumulative sleep deprivation may be affecting their RMR. Chronic insomnia can cause a dysregulation of certain hormones (cortisol, insulin and leptin). Insulin is a hormone that tells your body to store fat. Sleep deprivation appears to have a harmful impact on carbohydrate metabolism.

Muscle Loss/Softening of Muscle

From the time you are born to around the time you turn 30, your muscles grow larger and stronger. Generally, at some point in your 30s, you start to lose muscle mass and firmness. The cause is age-related sarcopenia (sarco = muscle; penia = deficiency).

Physically inactive people can lose as much as 5% to 7% of their muscle mass each decade after age 30. Even those who are active and workout will still experience age-related muscle loss.

There’s no test or specific level of muscle mass that will diagnose sarcopenia. Any loss of muscle matters because it affects strength, mobility, function, and reduces your metabolism and ability to burn calories.

Sarcopenia typically accelerates in one’s late fifties, but may also speed up as early as late forties or as late as mid seventies. It’s a factor in frailty and the likelihood of falls and fractures in older adults.

Symptoms can include weakness and loss of stamina, which can interfere with physical activity. Reduced activity further shrinks muscle mass.


What is NAD+?

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in all living cells that plays an important role in metabolism, including the transfer of energy from one molecule to another. It also helps regulate cellular processes such as DNA repair and protection, gene expression and other vital cellular functions.

What is the connection between NAD+ and aging?

As we age, our bodies produce less NAD+, which can lead to a decrease in energy production, an increase in oxidative stress and damage to DNA. Studies have shown that boosting NAD+ levels may help reduce the signs of aging and support healthy metabolic function.

How can NAD+ be boosted?

There are several ways to increase NAD+ levels, including exercise, dietary changes like cutting back on sugar and processed foods, and supplementation with certain vitamins and minerals such as nicotinamide riboside (NR), resveratrol or alpha lipoic acid.

What are the benefits of boosting NAD+ levels?

Boosting NAD+ levels can help improve energy production and reduce oxidative stress, which can help slow down the aging process. It may also protect DNA from damage and support metabolic processes such as fat burning and muscle growth. Additionally, studies have shown that it may improve cognitive function and reduce inflammation.